The correct answer is B) Upon the high seas and connecting waters navigable by seagoing vessels. This is correct because the International Regulations for Preventing Collisions at Sea (COLREGS), also known as the International Rules of the Road, apply to all vessels upon the high seas and in all waters connected to the high seas and navigable by seagoing vessels. These rules are designed to promote safe navigation and prevent collisions in international waters. The other options are incorrect because A) the rules apply to all international waters, not just those that are not inland waters, C) the rules apply universally to international waters regardless of which vessels are present, and D) the rules apply to international waters beyond the territorial waters of any single country.